Variosol ® advantages

  • Variosol ® is a fast, one step, high yield process suitable for pharmaceutical manufacturing of solid micronized powders and microspheres
  • Due to the direct contact of expanding CO2 with the atomized product, it is possible to micronize materials with low melting point or low Tg, under stable crystalline form
  • Cryogenic process conditions allow to formulate thermolabile molecules which could be otherwise damaged by high temperature processes, such as hot melt extrusion
  • Process can address different drug formulation issues with slight adjustment of operating parameters
  • Flexible process, offering the possibility to obtain micronized of different particles size powders with the same basic equipment. Different particles size makes applications to different delivery routes possible (e.g. oral,inhalatory, topical routes)
  • Variosol ® is a fast, one step, high yield process suitable for pharmaceutical manufacturing
  • Already established at lab scale, industrial scaleability proven in non pharmaceutical sectors (food and chemical industry)
  • "Green" Technology with low environmental impact. Variosol does not require the use of organic solvents in the process.
  • Green Technology. Variosol does not require the use of organic solvents.
  • Variosol is intrinsically simple and does not require complicated and costly equipment to scale. No need to operate at supercritical conditions.
  • Variosol ® minimizes or eliminates industrial costs associated with solvent removal and disposal, and with supercritical plants designs
  • Technology acceptability from environmental and regulatory perspectives