Why CryoXpand®?

Our technology is a mild, cryogenic spraying process to produce micronized powders in a non-oxidizing atmosphere of CO2 at low temperatures. These properties are very advantageous when dealing with thermally sensitive and oxidation-prone molecules, such as carotenoids or tocopherols.

CryoXpand® complies with several “green” sustainability principles, since it is a solvents-free, energy efficient process with low carbon dioxide consumption.

Oily, pasty or resinous natural materials are transformed into composite microspheres rich in bioactive substances in the form of flowable powders, for easy fill and finish in capsules, sachets or other dosage forms.

Micronized powders are also convenient for customers, as they can be easily mixed with water, juices or other beverages.

Case Studies


Astaxanthin (ASX) is a potent antioxidant, 10 times stronger than lutein and β-carotene. It has been found effective in diabetes, cardiovascular disease, some types of cancers, gastric ulcers, and as skin protectant against UV rays. Its use as a food supplement is limited by its very poor aqueous solubility and low stability to light, oxygen, high temperatures and extreme pHs. The combination of poor solubility and instability underlies astaxanthin scarce oral bioavailability.

AstaFast immediately releases ASX due to the lipid systems that help to improve bioavailability by facilitating the absorption through the lymphatic route, avoiding the 1st pass effect.

AstaCR is specifically designed to maintain the active bioaccesible for longer periods of time in comparison with the commercial product.

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  • Sitec PharmaBio
  • Sitec PharmaBio

Curcuminoids (curcumin, desmethoxycurcumin, 5'-methoxycurcumin and dihydrocurcumin) are potent antioxidant and anti-inflammatory agents, indicated for the treatment and prevention of numerous conditions such as rheumatoid arthritis, colon cancer, appetite loss or urinary tract infections.

Xcurcuma with its specific formulation and high curcumin load (25 %) can address the drawbacks of poor curcumin dispersibility in aqueous media. 

Our dissolution studies in supersaturation conditions show that in less than 10 minutes Xcurcuma is approximately 600 % more bioaccesible than the commercial 95 % curcumin extract.

On the other hand, CurcumaFast is designed to release the active immediately after oral administration.

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Lycopene is a thermosensitive carotenoid with high antioxidant properties, obtained from tomato peels extracts or from synthesis. It is water insoluble, highly hydrophobic and appears as viscous, oily-resinous material which is usually administered in liquid filled capsules.

We developed easy-to handle, water dispersible, stable microspheres of Lycopene in powder form. The lipid-composite structure of our microparticles facilitates particles dispersion in the intestinal fluids and the emulsification of lycopene combined with selected excipients