Innovative Cryospraying by eXpanding liquid dense CO2
Our cryospraying technology is based on the unique properties of rapidly expanding dense CO2 as congealing, atomizing and drying agent to produce microspheres in powder form.
During expansion, a cryogenic flow of CO2 works as a drying agent at low temperatures, leading to rapid atomization, particles formation and water removal from the solidifying product, also known as dewatering.
With CryoXpand® we develop lipid-composite formulations as solid micronized products for the pharmaceutical and nutraceutical markets. Target product properties can be achieved by suitable selection of functional excipients and control of process parameters.
Features
Microparticles by CO2 expansion
Cryogenic drying
Formulated systems
Scalability
Green technology
Circular economy
Equipment and process capability
The main challenges often faced by novel drug delivery technologies is the cost-effective transition from laboratory bench to larger scales of pilot, clinical and industrial manufacturing.
Cryospraying technology has the advantage to be already established in non-pharmaceutical sectors, where scalability to large volumes and process simplicity are required to guarantee business margins.
Lab Scale – Small Pilot Equipment
The equipment is designed with scalability criteria in mind, and with compact dimensions to fit in a small laboratory space. Lab scale feasibility tests, and small pilot runs (kilo-lab) can be performed. Modular and small scale units can be assembled and operated at clients’ sites.
Pilot Semi-Industrial Equipment
Through our collaboration with specialized engineering companies, pilot or large industrial scale equipment can be constructed to meet the User Requirements set by the client.
(Photo Courtesy of Messer R&D Center showing details of a pilot equipment with product capacity of 50 to 100 kg/hour, suitable for small industrial production).
