Cryospraying by near-critical carbon dioxide: solid microparticles with improved biopharmaceutical properties
Variosol ® is an innovative particle technology, based on the use of near-critical carbon dioxide. When expanding from near-critical conditions, CO2 has favourable physical properties as a spraying agent and refrigerant, and it can be used as an atomizing and crystallizing medium, generating microparticles with narrow size distribution and improved biopharmaceutical properties.
Variosol ® cryospraying technology can address many technical and economical challenges faced today by pharmaceutical industry. It offers significant advantages over existing micronization methods and over supecritical fluid based processes.